%A Wang Haohua, Chen Xiuxing, Guo Guifang %T exokinaseⅡ role in tumor growth and targeting therapyW %0 Journal Article %D 2017 %J Journal of International Oncology %R 10.3760/cma.j.issn.1673422X.2017.03.014 %P 213-216 %V 44 %N 3 %U {https://gjzlx.sdfmu.edu.cn/CN/abstract/article_10179.shtml} %8 2017-03-08 %X The energy for tumor cells mainly derives from the aerobic glycolysis, that is, the Warburg effect, which also provides a large amount of precursor substances for the growth of tumor cells. HexokinaseⅡ (HKⅡ), highly expressed in tumor tissue, is the ratelimiting enzyme of glycolysis and closely related to the energy metabolism of tumor. Recent studies have showed that HKⅡ not only mediates Warburg effect, but also promotes tumor proliferation by inhibiting tumor cell apoptosis and regulating autophagy. It has been confirmed that blocking HKⅡ gene expression and inhibiting HKⅡ with small molecule inhibitor can kill tumor cells in many kinds of cancer. Agent targeting HKⅡ may become a new generation of targeted drugs.