%A Sun Jirui, Zhou Bingjuan, Chen Hong, Ma Qiushuang, Zhang Jinku, Sun Zhe, Zhang Dongchen %T Expressions of HIF-1α and CA9 in breast carcinoma and their relationships with basal-like subtype %0 Journal Article %D 2017 %J Journal of International Oncology %R 10.3760/cma.j.issn.1673-422X.2017.06.004 %P 415- %V 44 %N 6 %U {https://gjzlx.sdfmu.edu.cn/CN/abstract/article_10220.shtml} %8 2017-06-08 %X ObjectiveTo study the expressions of hypoxia inducible factor1α (HIF1α) and carbonic anhydrase 9 (CA9) in different molecular subtypes of breast carcinoma and their relationships with basallike subtype. MethodsThe expressions of HIF1α and CA9 were detected by immunohistochemistry in five subtypes of breast carcinoma （n=803）. The relationships of the expressions of HIF1α and CA9 with the clinicopathologic parameters of basallike subtype and with the prognosis of patients were analyzed. ResultsThe positive expression rates of HIF1α and CA9 protein in breast carcinoma were much higher than those in paratumor breast tissues (43.96% vs. 3.86%, χ2=354.858, P<0.001; 19.80% vs. 4.61%, χ2=86.495, P<0.001). The positive expression rates of HIF1α in Luminal A, Luminal B, epidermal growth factor receptor2 (HER2) overexpression, basallike and normal breastlike subtypes were 31.97%, 25.00%, 56.06%, 77.89% and 55.76% respectively, and the positive expression rates of CA9 were 7.48%, 5.56%, 60.61%, 40.00% and 27.88% respectively, with significant differences (χ2=88.628, P＜0.001; χ2=147.128, P＜0.001). The positive expression rates of HIF1α and CA9 in estrogen receptor (ER)negative breast carcinomas (HER2 overexpression, basallike and normal breastlike) were significantly higher than those in ERpositive subtypes (Luminal A and Luminal B, all P<0.005). There was a significant positive correlation between HIF1α and CA9 (C=0.315, P=0.001), and both were correlated with the lymph node metastasis (χ2=4.542, P=0.033; χ2=7.025, P=0.008), pTNM stage (χ2=5.390, P=0.020; χ2=10.179, P=0.001) and poor prognosis (χ2=4.353, P=0.037; χ2=6.056, P=0.014) of basallike subtype. ConclusionOverexpressions of HIF1α and CA9 may be related to the ERnegative breast cancer more closely, and both may play important roles in the occurrence and development of basallike subtype. Overexpressions of HIF1α and CA9 may suggest the poorer prognosis of patients with basallike breast carcinoma.