%A Peng Wenmiao, Fu Hongxing, Yu Lifang, Rao Zhiguo %T Mechanism of anti-tumor effect of dihydroartemisinin %0 Journal Article %D 2017 %J Journal of International Oncology %R 10.3760/cma.j.issn.1673-422X.2017.06.012 %P 448- %V 44 %N 6 %U {https://gjzlx.sdfmu.edu.cn/CN/abstract/article_10233.shtml} %8 2017-06-08 %X Dihydroartemisinin (DHA), the major active metabolite of artemisinin, participates in tumor progression through the following ways: forming free radicals to induce cancer cells death dependent on iron, inducing apoptosis, inhibiting angiogenesis, tumor cells invasion and metastasis, modulating multidrug resistance, controlling intracellular Ca2+ concentration, regulating cell cycles, cell autophagy and the immune system and so on. Generally, it is considered to be a potential antitumor drug.