%A 朱晓雯，王晶，克晓燕 %T Co-stimulating molecule B7H3 and tumors %0 Journal Article %D 2017 %J Journal of International Oncology %R 10.3760/cma.j.issn.1673-422X.2017.11.011 %P 849-852 %V 44 %N 11 %U {https://gjzlx.sdfmu.edu.cn/CN/abstract/article_10349.shtml} %8 2017-11-08 %X B7-H3, a newly discovered co-stimulatory regulatory protein member of the B7 family. Its mRNA is ubiquitously expressed in a wide spectrum of tissues. As a co-stimulatory or co-inhibitory signal molecule which can regulate immune response, B7-H3 plays an important role in the immune system. Besides, B7-H3 can be also involved in cancer progression via nonimmunological. Recently, the aberrant expression of B7-H3 has been described in various malignancies, and significantly correlated with poor prognosis and cancer progression. Therefore, B7-H3 is considered as an early diagnostic and prognostic marker and therapeutic target for tumors, but the specific molecular mechanisms of B7-H3 regulation are poorly understood. The immune and gene therapy of tumor by target B7-H3 has made some progress.