%A Wang Yi, Su Xiaosan %T Mechanisms of tumor-derived exosomes promoting tumor metastasis %0 Journal Article %D 2018 %J Journal of International Oncology %R 10.3760/cma.j.issn.1673-422X.2018.11.009 %P 681-684 %V 45 %N 11 %U {https://gjzlx.sdfmu.edu.cn/CN/abstract/article_10545.shtml} %8 2018-11-08 %X Exosomes are microvesicles ranging from approximately 40-150 nm in size, which mediate the exchange of information between cells by releasing proteins, nucleic acids, etc. Tumor-derived exosomes (TEXs) may facilitate tumor metastasis through various mechanisms such as forming the premetastatic niche in the terminal organs, they can regulate immune cells and immune-related molecules in the tumor microenvironment to promote tumor immune escape, they can also induce tumor angiogenesis and increase vascular permeability, promoting the epithelial-mesenchymal transformation of tumor cells, etc. Understanding the mechanism of TEXs in tumor metastasis can provide new ideas for effective prevention and treatment of tumor metastasis.