%A Gao Hui, Yi Shanyong, Yang Bin, Ma Xiwen, Zhao Ling %T Antitumor mechanism of metformin and its effect on targeted drugs %0 Journal Article %D 2018 %J Journal of International Oncology %R 10.3760/cma.j.issn.1673-422X.2018.12.010 %P 747-750 %V 45 %N 12 %U {https://gjzlx.sdfmu.edu.cn/CN/abstract/article_10562.shtml} %8 2018-12-08 %X With the advent of the era of accurate medical treatment, molecular targeted therapy has become a new trend of cancer treatment. The abnormal status of cancer metabolism and metabolic drug together with tumor targeted therapy are becoming the hotspot in cancer. A large number of studies have shown that metformin, a targeted metabolic drug, has synergistic antitumor effects when it is used in combination with various target drugs. The combination of targeted metabolic drugs and antitumor drugs can provide new strategies for tumor treatment.