m⁶A methylation can regulate RNA metabolism and participates in the pathogenesis of breast cancer. m⁶A methyltransferase, demethylase and methylated binding protein regulate the dynamic and reversible process of m⁶A methylation modification together. In recent years, studies have shown that methyltransferase-like (METTL)3, MELLT14, KIAA1429, fat-mass and obesity associated protein, YTH domain family member 1-3 and other related factors are abnormally expressed in breast cancer, which may affect the occurrence and development of breast cancer by regulating the methylation and demethylation process of m⁶A. Further studies will provide a new idea and target for clinical diagnosis and treatment of breast cancer.