Lumican is a member of the small leucine-rich proteoglycan family，which is involved in cell processes related to tumorigenesis and development，such as epithelial-mesenchymal transition，cell proliferation，migration，invasion and adhesion. The expression of Lumican in different tumors is positively or negatively correlated with tumor progression，and can be used as a reference for tumor prognosis and efficacy evaluation. Further study of the correlation and potential mechanism between Lumican and tumor therapy resistance can provide new ideas for predicting clinical therapeutic efficacy.