ObjectiveTo investigate the efficacy and safety of bevacizumab combined with capecitabine in the treatment of advanced breast cancer.MethodsSeventy-six patients with advanced breast cancer who were diagnosed in the Cancer Center of the People's Liberation Army Navy Anqing Hospital from August 2019 to May 2021 were selected. According to different treatment schemes， the patients were divided into the control group （using single drug capecitabine） and the test group （using bevacizumab combined with capecitabine）， with 38 cases in each group. After 4 cycles of treatment， the clinical efficacy， progression-free survival （PFS）， overall survival （OS） and adverse reactions were compared between the two groups， and the levels of vascular endothelial growth factor （VEGF）-121， VEGF-145， VEGF-165 and quality of life before and after treatment were compared.ResultsThe objective remission rate of the test group [57.89% （22/38）] was higher than that of the control group [42.11% （16/38）]， but there was no statistically significant difference （χ²=1.89，P=0.169）； The disease control rate of the test group [81.58% （31/38）] was better than that of the control group [55.26% （21/38）]， there was a statistically significant difference （χ²=6.09，P=0.014）. The median PFS of patients in the test group （6.3 months） was longer than that in the control group （4.2 months）， there was a statistically significant difference （χ²=0.48，P=0.003）； The median OS of patients in the test group （14.8 months） was not significantly different from that in the control group （13.2 months） （χ²=0.15，P=0.704）. After treatment， the expression level of serum VEGF-121 [（201.25±18.37） ng/Lvs.（276.83±20.26） ng/L]， VEGF-145 [（102.24±12.16） ng/Lvs.（170.39±15.28） ng/L]， VEGF-165 [（135.08±14.32） ng/Lvs.（210.53±16.09） ng/L] in the test group was lower than that in the control group， there were statistically significant differences （t=17.03，P<0.001；t=21.51，P<0.001；t=21.59，P<0.001）. After treatment， patients in the test group were assessed according to 36-item Short-Form （SF-36） physiological function [（80.18±13.96） scorevs.（71.72±16.12） score]， physiological function [（67.19±30.62） scorevs.（53.12±9.86） score]， physical pain [（70.01±17.97） scorevs.（61.06±17.57） score]， overall health [（68.67±18.92） scorevs.（57.96±20.97） score]， vitality [（78.39±19.37） scorevs.（68.26±18.52） score]， social function [（82.24±19.73） scorevs.（70.92±20.31） score]， the scores of emotional function [（73.81±28.86） scorevs.（60.23±29.19） score] and mental health [（76.19±12.82） scorevs.（70.31±12.54） score] were higher than those of the control group， there were statistically significant differences （t=2.45，P=0.017；t=2.03，P=0.046；t=2.19，P=0.031；t=2.34，P=0.022；t=2.33，P=0.023；t=2.46，P=0.016；t=2.04，P=0.045；t=2.02，P=0.047）. The incidence of adverse reactions in the test group [18.42% （7/38）] was lower than that in the control group [76.32% （29/38）]， there was a statistically significant difference （χ²=25.54，P<0.001）.ConclusionThe combination of bevacizumab and capecitabine chemotherapy has a higher clinical effect on advanced breast cancer， which can significantly reduce the level of VEGF in patients， improve the quality of life of patients， with mild adverse reactions and high safety.