E2F1， a nucleoprotein gene belongs to transcription factor， is closely associated with the development of malignant tumours. Long non-coding RNAs （lncRNAs） are aberrantly expressed in a variety of tumors. In studies of molecular mechanisms associated with lncRNAs and tumours， E2F1 has been identified as a key factor that can play a critical role as an upstream regulator or downstream target of lncRNAs， and even inter-regulate to form a positive feedback loop. This paper reviews the significance of the interaction between E2F1 and lncRNA in malignant tumors in recent years， and aims to provide ideas for the study of tumor mechanisms.