Angiopoietin-like protein 4 （ANGPTL4） is involved in the regulation of glucose and lipid metabolism and angiogenesis，and is closely related to tumorigenesis，development，invasion and metastasis. The abnormal expression of ANGPTL4 gene can promote or inhibit the growth and proliferation of tumor cells and play a tumor-promoting or anti-tumor role in the occurrence and development of tumors. To explore the role of ANGPTL4 gene in the occurrence and development of different tumors can provide reference for evaluating the diagnosis，prognosis and curative effect of tumors.