%A Shao Huifang, Wang Xuehong, Lu Yongfu %T Mechanism of action and clinical significance of CST1 in the progression of gastric cancer %0 Journal Article %D 2023 %J Journal of International Oncology %R 10.3760/cma.j.cn371439-20230308-00093 %P 489-492 %V 50 %N 8 %U {https://gjzlx.sdfmu.edu.cn/CN/abstract/article_11330.shtml} %8 2023-08-08 %X

Cysteine protease inhibitor 1 （CST1） is a member of type 2 Cystatins superfamily, plays a key role in targeted regulation. CST1 is highly expressed in gastric cancer, promotes tumor cell migration and invasion by activating the epithelial-mesenchymal transformation pathway and Wnt pathway, and regulates tumor growth and progression in combination with the corresponding target genes of homeobox C10 and glutathione peroxidase 4. A deeper understanding of the role and function of CST1 in gastric cancer will help to further develop potential therapeutic targets and diagnostic and prognostic markers for gastric cancer.