The histopathological growth patterns （HGPs）of colorectal cancer （CRC）liver metastasis reflect the complicated and varied interactions between tumor cells and host microenvironment. Exploring the tumor vascular and immunological features of HGPs，the relationship between HGPs and anti-tumor treatment efficacy，and HGPs prediction methods may have potential clinical aplication value for making optimal treatment strategies，evaluating patients' prognosis，and monitoring disease progression.