Breast cancer is the most common malignant tumor among women， and early diagnosis， coupled with optimized treatment strategies is crucial for improving the prognosis. In recent years， with the advancement of nanotechnology， manganese-based nanomaterials have shown potential in various aspects of early breast cancer diagnosis， drug delivery， and tumor treatment. Compared to other nanomaterials， manganese-based nanomaterials exhibit excellent biocompatibility and have become a significant focus in the research of breast cancer diagnosis and treatment.