%A GUO Shu-Qin, ZHU Chun-Ying, ZHANG Yun-Liang %T SIRT1 and neoplasms. %0 Journal Article %D 2011 %J Journal of International Oncology %R %P 569-571 %V 38 %N 8 %U {https://gjzlx.sdfmu.edu.cn/CN/abstract/article_8548.shtml} %8 2011-08-08 %X SIRT1 (Sirtuin type 1) is dependent on nicotinamide adenine dinucleotide (NAD +) group Protein deacetylase involved in the covalent modification of histones, participated in tumor development and progression through transcription, translation and post-translational modification and so on. Therefore， the expression of SIRT1 in tumor cells or abnormal function could be one of the important mechanisms of tumor development，and may become a new potential therapeutic targets for cancer