%A YANG Shuo, GAO Ai %T Tumor-related miRNA targeting PTEN %0 Journal Article %D 2011 %J Journal of International Oncology %R %P 732-735 %V 38 %N 10 %U {https://gjzlx.sdfmu.edu.cn/CN/abstract/article_8583.shtml} %8 2011-10-08 %X MicroRNAs are the endogenous non-coding RNAs that regulate gene expression by mediating gene post-transcriptional silence. Among them, miR-21, miR-17-92, miR-214, miR-26a, miR-221, miR-222 and so on mainly suppress the expression of PTEN phosphohydrolase through targeting PTEN mRNA 3’-UTR. PTEN plays an important role in cell proliferation, apoptosis, migration and invasion, and its low expression will induce tumorigenesis.