%A ZHANG Qi-Yao, XU Hong-Tao %T Role of thyroid cancer-1 in tumorigenesis and progression %0 Journal Article %D 2012 %J Journal of International Oncology %R %P 83-85 %V 39 %N 2 %U {https://gjzlx.sdfmu.edu.cn/CN/abstract/article_8687.shtml} %8 2012-02-08 %X Thyroid cancer-1, a nuclear protein coded by TC-1( C8orf4), regulates the cell cycle, participates transcription and translation, and is correlated with the proliferation of normal and cancer cells. TC-1 participates in the Wnt/beta-catenin signaling pathway which can promote the up-regulation of proto-oncogene. Hence it plays an important role in the malignant tuansformation and development of the tumors, such as thyroid cancer, gastric cancer and breast cancer. Therefore, as a potential tumor-associated protein, it’s likely to be used for fundamental research and gene targeting therapy.