%A HUANG Fan, LI Yuan, PENG Ming-Qing %T Expression and regulation of P-glycoprotein mediated by cellular microenvironment in cancer %0 Journal Article %D 2012 %J Journal of International Oncology %R %P 92-95 %V 39 %N 2 %U {https://gjzlx.sdfmu.edu.cn/CN/abstract/article_8690.shtml} %8 2012-02-08 %X Expression and regulation of the P-glycoprotein (P-gp) is associated withthe development of multidrug resistance in cancer. Cancer cells are exposed inendogenous damages from its own micro-environments and inflicted stimulated damages. These harmful micro-environments could trigger cellular stress response and regulated the expression of P-gp through various activated signal transduction pathways. Researches of the cellular endogenous micro-environments and exogenous stimulation damages on the expression and regulation of P-gp would have important significancefor exploring the multidrug resistance of cancer cell.