%A CHENG Yu-Sheng, XIA Jing-Yan, XU Feng %T Polyinosinic-polycytidylic acid and tumor immunity %0 Journal Article %D 2012 %J Journal of International Oncology %R %P 252-254 %V 39 %N 4 %U {https://gjzlx.sdfmu.edu.cn/CN/abstract/article_8755.shtml} %8 2012-04-08 %X Polyinosinic-polycytidylic acid is a synthetic analog of double-stranded RNA, which plays a vital role in the regulation of immune system. Toll-like receptor 3 (TLR3 ), melanoma differentiation-associated gene 5 (MAD-5) and retinoic acid inducible gene -Ⅰ (RIG-Ⅰ) are the main three intracellular receptors binding to polyinosinic-polycytidylic acid which activates human anti-tumor immune responses including the activation of innate immunity and acquired immunity through TIR-domain-containing adapter-inducing interferon-β (TRIF) and interferon-β. Thus, polyinosinic-polycytidylic acid plays an important role in regulating anti-tumor immune responses. The immunoregulation mechanisms of polyinosinic-polycytidylic acid in melanoma, breast cancer, malignant glioma and lung cancer have been clarified, which will provide new strategies for tumor immunotherapy.