%A SUN Wen, CHEN Jin-Fei %T Variations of biomarkers in gastrointestinal stromal tumor and prognoses of the patients and targeted drug sensitivity%0 Journal Article %D 2012 %J Journal of International Oncology %R %P 295-298 %V 39 %N 4 %U {https://gjzlx.sdfmu.edu.cn/CN/abstract/article_8768.shtml} %8 2012-04-08 %X Many researches show that the prognosis of gastrointestinal stromal tumor (GIST) are related to numerous variations of biomarkers such as numeric chromosomal aberrations or nuclear/mitochondrial microsatellite instability. In addition, the changes of proto-oncogene and tumor-suppressor gene are found to influence the prognosis of GIST. The kit and platelet-derived growth factor receptor a mutation are correlated with GIST progression, metastasis and targeted drug sensitivity, and then influence the prognosis of GIST.