%A GUO Cui-ping %T Regulation of cyclin E and cancers %0 Journal Article %D 2012 %J Journal of International Oncology %R %P 337-340 %V 39 %N 5 %U {https://gjzlx.sdfmu.edu.cn/CN/abstract/article_8779.shtml} %8 2012-05-08 %X Cyclin E is expressed starting from the middle G1 phase of the cell cycle, and is accumulated in the G1/S boundry. Cyclin E binds to and activates the cyclindependent kinase CDK2. Cyclin E-CDK2 complex initiates a cascade of events that leads to DNA replication by phosphorylating its substrates, such as Rb, CDC6, NPAT and P107, etc. Additionally, cyclin E plays an important role in the regulation of genomic stability, spindleorganizing structure and centrosome cycle. Cyclin E expression is transactivated by members of the transcription factor E2F family and degrades via the ubiquitinproteasome pathway. At the same time, it is also negatively regulated by the CIP/KIP proteins. Cyclin E highly expressed in the initiation and progression of different human cancers, such as breast cancers, lung cancers, leukemia, lymphomas and others.