%A XU Chun-hong %T Epithelial-mesenchymal transition in digestive system tumors %0 Journal Article %D 2012 %J Journal of International Oncology %R %P 380-383 %V 39 %N 5 %U {https://gjzlx.sdfmu.edu.cn/CN/abstract/article_8790.shtml} %8 2012-05-08 %X Recent studies show that tumor cells get rid of the connections between cells, and induce tumor invasion and metastasis through epithelialmesenchymal transition (EMT). EMT becomes an important way to invasion, metastasis and chemotherapy resistance of epithelial cell carcinoma which accounting for more than 90% of malignant carcinomas. Members of Snail family, especially Snail is regarded as important adjustment factor of EMT, which induce the transformation from epithelial cell to mesenchymal phenotype through competitive inhibition Ecalcium protein gene expression. Many researches show that EMT exists widely in digestive system tumors, which is closly related to the invasion, metastasis and chemotherapy resistance of digestive system tumors.