%A LI Yan-Jie %T Clinical study of ocular damnification after intensity-modulated radiotherapy in patients with nasopharyngeal carcinoma %0 Journal Article %D 2012 %J Journal of International Oncology %R %P 472-476 %V 39 %N 6 %U {https://gjzlx.sdfmu.edu.cn/CN/abstract/article_8816.shtml} %8 2012-06-08 %X Objective To study the effect on normal ocular tissues after intensity-modulated radiotherapy (IMRT) in the patients with nasopharyngeal carcinoma. Methods Nineteen nasopharyngeal carcinoma patients confirmed by pathology were enrolled (38 eyes). All Patients underwent visual acuity, slit lamp, fundus, visual evoked potential (VEP) and electroretinograms (ERG) examination before IMRT, at the end of IMRT, 6 months and 12 months after IMRT. Results ① There was no statistically difference in uncorrected and corrected visual acuity at the various examination time points before and after radiotherapy (P＞0.05). ② Theaverage latency of VEP P
100before IMRT,at the end of IMRT, at 6 months after IMRT and 12 months after IMRT was (99.684±2.484) μV , (99.947±2.277) μV, (104.000±3.952) μV and (101.316±2.462) μV respectively. The average latency of VEP P
100was significantly prolonged at 6 months after IMRT compared with the time points of before IMRT, the end of IMRT and 12 months after IMRT (P＜0.05). ③ The average latency of ERG b wave before IMRT , at the end of IMRT, at 6 months after IMRT and 12 months after IMRT was (44.974±3.774) ms, (44.816±3.368) ms, (43.184±2.837) ms and (44.000±3.154) ms respectively。The average amplitude of ERG b wave before IMRT, at the end of IMRT, at 6 months after IMRT and 12 months after IMRT was (421.237±27.353) μV, (414.763±26.188) μV, (419.026±24.876) μV, and (419.974±25.894) μV respectively. No statistically difference was found in average latency and amplitude of ERG b wave at the various examination time points before and after radiotherapy (P＞0.05). ④ The average amplitude of Op2 wave before IMRT, at the end of IMRT, at 6 months after IMRT and 12 months after IMRT was (63.184±6.028) μV, (48.605±6.872) μV, (50.421±6.769) μV and (53.026±6.074) μV respectively. At the various time points after IMRT, the average amplitude of Op2 wave was significantly lower than before IMRT (P＜0.05).Conclusion IMRT can significantly reduce the incidence of ocular complications. There is a good clinical application value of ERG and VEP for evaluating retina and optical nerve functional changes induced by IMRT.