%A QIAO En-qi, TANG Jin-Hai, WU Jian-Zhong %T Pregnane X receptor and tumor multidrug resistance %0 Journal Article %D 2012 %J Journal of International Oncology %R %P 489-492 %V 39 %N 7 %U {https://gjzlx.sdfmu.edu.cn/CN/abstract/article_8820.shtml} %8 2012-08-06 %X The overexpression of P-glycoprotein (P-gp) and its coding gene mdr1 is regarded as the classic mechanism of multidrug resistance (MDR). Recent studies find that pregnane X receptor (PXR) can mediate the expression of P-gp. It is confirmed that PXR can also inhibit apoptosis of tumor cells. Therefore, preventing the activation of PXR specifically may be a new method to prevent MDR.