%A WANG Wei-Min, DENG Jian-Liang, ZHOU Yan %T Cullin1 and malignant tumors %0 Journal Article %D 2012 %J Journal of International Oncology %R %P 818-820 %V 39 %N 11 %U {https://gjzlx.sdfmu.edu.cn/CN/abstract/article_8919.shtml} %8 2012-11-08 %X Cullin1 is a member of the cullin genome. The cullin1 assembly complex has typical ubiquitin ligase activity, and mediates cell cycle proteins, especially cancer-associated protein degradation process, an then effectively regulates the cell cycle progression. Cullin1 play an important role in the genesis and development of malignant tumors.