%A WANG Qing, ZHANG Lu, SHEN Qian-Ni, ZHU Ni, LUO Fan, HOU Wei %T Anti-tumor effect of Type Ⅲ interferon %0 Journal Article %D 2012 %J Journal of International Oncology %R %P 905-907 %V 39 %N 12 %U {https://gjzlx.sdfmu.edu.cn/CN/abstract/article_8945.shtml} %8 2012-12-08 %X It is reported that type Ⅲ interferon (IFN-λ) has an anti-tumor effect on melanoma, hepatocellular carcinoma, esophageal carcinoma and fibrosarcoma in recent years. IFN-λ could not only inhibit melanoma metastasis, but also induce cell apoptosis; its constitutively expression could activate natural killer cells, affecting hepatocellular carcinoma growth; IFN-λ could induce cells of G ₁phase in esophageal carcinoma directly to stagnation or apoptosis; IFN-λ could cause native and adaptive immune response to suppress fibrosarcoma growth. Research on the anti-tumor mechanisms of IFN-λ will provide new ideas for clinical tumor therapy.