%A SHEN Jue, LI Yu-Feng, HE Zhen-Juan %T Research progress of FLIP in cancer %0 Journal Article %D 2013 %J Journal of International Oncology %R %P 83-85 %V 40 %N 2 %U {https://gjzlx.sdfmu.edu.cn/CN/abstract/article_8984.shtml} %8 2013-02-08 %X FLIP is a protein containing death domain. Human beings have three subtypes of c-FLIP _L, c-FLIP _Sand c-FLIP _R, which can inhibit the apoptosis of a variety of tumor cells. C-FLIP _Lplays a dual role in the apoptotic signal. The expression level of FLIP not only decides the opening and closing of the apoptosis pathway but also achieve the conversion of cells in the apoptotic signaling and proliferative signaling pathway. The regulation of FLIP’s expression is a multi-layered, involving multiple signaling pathways. FLIP will probably become an attractive death receptor signaling target of therapy.