%A DING Xiang-Ping, ZHANG Jin-Hua %T Oncogenic mechanism and biological effect of Evi-1 gene %0 Journal Article %D 2013 %J Journal of International Oncology %R %P 170-173 %V 40 %N 3 %U {https://gjzlx.sdfmu.edu.cn/CN/abstract/article_9010.shtml} %8 2013-03-08 %X Ecotropic viral integration site-1 (Evi-1) gene is first identified as a binding site for retrovirus in murine myeloid leukemia. The human homologue withthe murine in leukemia oncogene Evi-1 is about 91% of nuclear sequence and 94% of amino acid. Evi-1 gene is high expressed in myeloid malignancies and other tumors. The main tumorigenic mechanisms of Evi-1 gene include inhibiting TGF-β signal path by depressing Smad3, adjusting cell cycle, promoting angiogenesis, inhibiting JNK, activating AP-1, and so on.