%A XU Xue-Zong, CAO Jing-Yan, YU Yan %T Mel-18 gene and neoplasms %0 Journal Article %D 2013 %J Journal of International Oncology %R %P 246-249 %V 40 %N 4 %U {https://gjzlx.sdfmu.edu.cn/CN/abstract/article_9032.shtml} %8 2013-04-08 %X Mel-18 gene is one of the core members of the PcG (polycomb group,) family,which plays an important role in embryogenesis, cell growth and proliferation and self-renewal of stem cells. Mel-18 gene expressing abnormally has been related to human tumorigenesis, development process. Mel-18 serves as a tumor suppressor gene and inhibits tumor growth through transcriptional repression of Bmi-1 and c-myc. Mel-18 expression is decreased at transcriptional and translational levels in most human cancers including breast cancer, prostate cancer, and gastric cancer and other tumors. Mel-18 is expected to become a prognostic marker for human cancers.