%A YAO Zhi-Feng, YAO Jian-Xin, LIU Yong-Biao %T Antitumor effect of piplartine and its mechanism %0 Journal Article %D 2013 %J Journal of International Oncology %R %P 259-263 %V 40 %N 4 %U {https://gjzlx.sdfmu.edu.cn/CN/abstract/article_9041.shtml} %8 2013-04-08 %X Piplartine is an alkaloids/amide component of Piper species, having diverse pharmacological and biological activities. Recent studies have indicated that piplartine has inhibitory effects on several kinds of tumors and is a potential antitumor drug. It can inhibit the proliferation of tumor cells, cause cell cycle arrest and induce apoptosis. More investigations suggest targeting the reactive oxygen species(ROS) stress-response pathway is closely related to its antitumor activity.