%A LI Na, JIA Xiu-Hong %T FHIT gene and tumor%0 Journal Article %D 2013 %J Journal of International Oncology %R %P 563-566 %V 40 %N 8 %U {https://gjzlx.sdfmu.edu.cn/CN/abstract/article_9139.shtml} %8 2013-08-08 %X The human fragile histidine triad (FHIT)gene is a tumor suppressor gene, which is located at chromosome region 3p14.2.The fragile site FRA3B ofthe FHIT gene is the most unstable site. FHIT can promote apoptosis, and inhibitcell proliferation and tumorigenesis. High methylation status, loss of the various sections of the FHIT gene, changes of the fragile site FRA3B and abnormalities of FHIT transcripts can result in gene afunction, and then promote the development and progression of various types of cancers. Transfecting wild-type FHIT into tumor cells with low or lacking endogenous FHIT expression can induce apoptosis. The combined treatment with other genes may provide a new insight for the treatment of tumors.