%A YE Ying-Nan, WANG Yue, WANG Yang, et al %T Molecular mechanisms of epithelial-mesenchymal transition in hepatocellular carcinoma%0 Journal Article %D 2013 %J Journal of International Oncology %R %P 608-611 %V 40 %N 8 %U {https://gjzlx.sdfmu.edu.cn/CN/abstract/article_9154.shtml} %8 2013-08-08 %X The poor prognosisof hepatocellular carcinoma (HCC) is strongly associated with invasion and metastasis. Recently, the epithelial-mesenchymal transition(EMT) has been confirmed to be the cytological foundationof invasion and metastasis. Yet, the molecular mechanismof inducing and maintaining EMT has not been expounded completely. However,it has been demonstrated that transforming growth factor-β(TGF-β), phosphatidyl inositol 3-kinase/ protein kinase B( PI3K/AKT),nuclear factor-κB(NF-κB),Wnt/β-catenin signaling pathways play pivotal roles in the initiation and development of EMT. These signalingpathways can affect the prognosisof HCC by regulating EMT. From a drug development perspective, these signal pathways are potential and attractive targets for HCC treatment.