%A LIANG Zhi-Jie, JIA Miao-Miao, ZHANG Bin, et al %T Roles of Pim-1 in tumors and related signaling pathways %0 Journal Article %D 2013 %J Journal of International Oncology %R %P 723-726 %V 40 %N 10 %U {https://gjzlx.sdfmu.edu.cn/CN/abstract/article_9187.shtml} %8 2013-10-08 %X The overexpression of proto-oncogene proteins c-pim-1 ( Pim-1) in tumor tissue is related to the stage and prognosis. Recent studies indicate that Pim-1 plays a critical role in the proliferation and apoptosis of cells and the metastasis of tumor. Pim-1 acts as an essential factor in several signaling pathways and its expression and activation are regulated by many factors as well as affects others widely. As an influential factor in the occurrence and development of tumor, Pim-1 has been a potential target in oncotherapy.