%A WU Jing, YANG Rui, LIU Shu-Ye %T Mechanisms and reversal strategies of tumor multidrug resistance %0 Journal Article %D 2013 %J Journal of International Oncology %R 10.3760/cma.j.issn.1673-422X.2013.12.003 %P 889-892 %V 40 %N 12 %U {https://gjzlx.sdfmu.edu.cn/CN/abstract/article_9212.shtml} %8 2013-12-10 %X Tumor multidrug resistance (MDR) is the leading cause of clinical chemotherapy failure and death. Researches show that the occurrence of MDR is related to Pglycoprotein, multidrug resistanceassociated proteins, breast cancer resistanceassociated proteins, lung resistancerelated proteins and other factors. Now the reversal strategies of MDR include chemical drugs reversal, gene reversal, immune reversal, traditional Chinese medicine reversal and drugloaded nanosystem reversal, which make some progress and help to improve the effect of cancer chemotherapy.