%A DENG Chun-Yan, TAN Xiao-Qin, LI Tao, HUANG Jian-Ming %T EMT mediated cancer stemness and tumor %0 Journal Article %D 2013 %J Journal of International Oncology %R 10.3760/cma.j.issn.1673-422X.2013.12.006 %P 899-902 %V 40 %N 12 %U {https://gjzlx.sdfmu.edu.cn/CN/abstract/article_9215.shtml} %8 2013-12-10 %X Epithelialmesenchymal transition (EMT) is a major mechanism in tumor metastasis. As the key regulatory factor, Twist gene plays an important role in EMT, and it can be induced by radiotherapy, chemotherapy and a variety of cytokines. Researches show that tumor cells can get stem celllike properties via EMT, which can lead to chemoradiotherapy resistance, tumor angiogenesis and distant metastasis. EMT has a great influence on the prognosis of tumor, and it is expected to become an important target for tumor treatment.