%A PENG Jing-Tao, MO Ren, FAN Jie %T A double-negative feedback loop lin28-let-7 and tumor %0 Journal Article %D 2014 %J Journal of International Oncology %R 10.3760/cma.j.issn.1673-422X.2014.03.002 %P 165-168 %V 41 %N 3 %U {https://gjzlx.sdfmu.edu.cn/CN/abstract/article_9320.shtml} %8 2014-03-08 %X The microRNA let-7 family, functioning as a tumor suppressor, has emerged as a regulator of stem cell differentiation and tumor repression. The RNA-binding protein lin28 is a stem cell pluripotency factor, which contributes to the maintenance of stem cell characteristics and promoting cell malignant transformation. lin28 can block the maturity of let-7 by combining with the precursors of let-7 family miRNAs, which is itself able to repress lin28 by binding to the 3′-UTR of lin28 transcripts, thus forming a feedback loop. The doublenegative feedback loop comprising lin28 and let-7 is involved in several biological processes such as differentiation of stem cell, tumorigenesis, invasion and metastasis, drug resistance and relapse, which could be a potential target for cancer therapy.