%A LUO Xin-Yue, HU Rui-Cheng, DAI Ai-Guo %T Research progress of D4-GDI in the pathogenesis of lung cancer %0 Journal Article %D 2014 %J Journal of International Oncology %R 10.3760/cma.j.issn.1673-422X.2014.03.014 %P 206-208 %V 41 %N 3 %U {https://gjzlx.sdfmu.edu.cn/CN/abstract/article_9332.shtml} %8 2014-03-08 %X As one of the main members of the Rho GDI dissociation inhibitory factors, D4-GDI inhibits the dissociation of Rho protein and GDP, which is also involved in a wide range of celluar functions, such as cell contraction, adhesion, migration, proliferation and apoptosis. Recently, accumulating evidence has been suggested that D4-GDI is involved in the pathogenesis of several pulmonary diseases, such as lung cancer. Intervention of D4-GDI expression may improve the pathological changes and prognosis of these diseases.