%A ZHUANG Yan, LIU Li-Gen %T JAK/STAT pathway and its role in acute leukemia %0 Journal Article %D 2014 %J Journal of International Oncology %R 10.3760/cma.j.issn.1673-422X.2014.06.021 %P 460-463 %V 41 %N 6 %U {https://gjzlx.sdfmu.edu.cn/CN/abstract/article_9390.shtml} %8 2014-06-08 %X JAK/STAT pathway is a central signaling activated by cytokines binding with their relative receptors which can regulate cell proliferation, differentiation and apoptosis. Recent studies have suggested that abnormal signaling pathway with gene mutation and dysregulation plays an important part in the pathogenesis and progression of acute leukemia. Increasing investigation of this pathway may provide novel target therapies.