%A ZHENG Jin, LIN Ying-Cheng %T Research progress of kinetochore protein CENPF in malignant tumor %0 Journal Article %D 2014 %J Journal of International Oncology %R 10.3760/cma.j.issn.1673422X.2014.07.006 %P 500-502 %V 41 %N 7 %U {https://gjzlx.sdfmu.edu.cn/CN/abstract/article_9419.shtml} %8 2014-08-04 %X CENPF is a cellcycle dependent kinetochore protein, whose expression and localization patterns are regulated in a cell cycledependent manner. CENPF plays an important role in the development and progress of malignant tumor. The expression of CENPF is upregulated in many tumors. It serves as an important marker in cell proliferation. Studies have demonstrated that CENPF is involved in tumor genesis, progress, invasiveness, relapse and prognosis. CENPF might be a valuable prognostic marker and potential therapy target in cancer treatment.