%A Zhang Yue, Zhao Liang %T Expression and regulatory mechanism of microRNA-133 in tumor %0 Journal Article %D 2014 %J Journal of International Oncology %R 10.3760/cma.j.issn.1673-422X.2014.09.001 %P 641-644 %V 41 %N 8 %U {https://gjzlx.sdfmu.edu.cn/CN/abstract/article_9464.shtml} %8 2014-09-25 %X As small non-coding RNAs, microRNAs (miRNAs) have been recognized as important regulatory factors in the posttranscription regulation network. Studies have shown that miR-133a and miR-133b, as members of miR-133 family, can regulate the expression of target genes such as epidermal growth factor receptor and oncogene. They regulate the mitogen-activated protein kinases and protein kinase B signaling pathways, which affect tumor cell proliferation, invasion and migration. MiR-133 plays a key role in the process of tumor development and progression, suggesting that it could be served as a new target for cancer treatment.