%A Zhang Xintong, Yue Wentao %T Alternative splicing of tumor associated genes messenger RNA and application %0 Journal Article %D 2014 %J Journal of International Oncology %R 10.3760/cma.j.issn.1673422X.2014.09.003 %P 648-651 %V 41 %N 8 %U {https://gjzlx.sdfmu.edu.cn/CN/abstract/article_9466.shtml} %8 2014-09-25 %X As a way of gene modification, alternative splicing is an important factor of eukaryotic gene expression and regulation. It makes various transcripts from one proteincoding gene, and greatly extends the genetic information. Alternative splicing of premessenger RNA plays an important role in tumor cells. By alternative splicing, some important genes can generate splicing variants different from those in normal cells. The existence of tumorspecific splicing variants leads to the occurrence and progression of tumor. Therefore, exploration on the alternative splicing of tumorassociated genes may be of great significance in tumor diagnosis and treatment.