%A Du Tianxing, Yang Jiyuan, Li Long, Zhao Huichuan, Chen Tingxuan, Li Junchuan %T Expression and significance of β-catenin in gastric adenocarcinoma and the metastasis of lymphnode %0 Journal Article %D 2014 %J Journal of International Oncology %R 10.3760/cma.j.issn.1673-422X.2014.09.016 %P 696-699 %V 41 %N 8 %U {https://gjzlx.sdfmu.edu.cn/CN/abstract/article_9479.shtml} %8 2014-09-25 %X ObjectiveTo explore the expressions of βcatenin in gastric adenocarcinoma primary tumors and metastatic lymph nodes， and to determine if it is associated with infiltration degree and whether it can provide the basis for gastric cancer metastasis. MethodsThe expressions of βcatenin were detected in 156 patients with gastric adenocarcinoma specimens, 40 cases with the corresponding lymph nodes and 12 cases of normal gastric tissues by the method of immunohistochemistry. The expressions of βcatenin in gastric adenocarcinoma and corresponding lymph node metastases were analysed. The relationship between the expression of βcatenin and the clinical pathological features of gastric adenocarcinoma was ascertained, and difference between them was observed. ResultsThe positive expression rate of βcatenin in normal gastric tissue membrane was 100.0%(12/12). The expression rate of βcatenin was 29.5% (46/156) in adenocarcinoma cell membrane, and it was 10.0% (4/40) in metastatic lymph nodes cell membrane. The positive expression of βcatenin was not associated with patient′s age(χ2=2.160, P=0.142), gender (χ2=1.229, P=0.268), but it was associated with tumor infiltration degree (χ2=4.032, P=0.045), degree of tumor differentiation (χ2=6.093, P=0.048), tumor stage (χ2=4.591, P=0.032), and metastasis lymph nodes (χ2=4.485, P=0.034). The incidence of abnormal or loss expression of βcatenin in gastric adenocarcinoma metastatic lymph nodes was higer than that in gastric adenocarcinoma (χ2=6.362, P=0.012). ConclusionThe expression of βcatenin will be a great help to judge the biological behaviors such as the malignant degree of tumor and the capacity of tumor invasion and metastasis.