%A CHEN Ke-Jun, LYU Shu-Qing %T Resistant mechanism about rapamycin and solution %0 Journal Article %D 2014 %J Journal of International Oncology %R １０．３７６０／ｃｍａ．ｊ．ｉｓｓｎ．１６７３４２２Ｘ．２０１４．１０．００７ %P 740-743 %V 41 %N 10 %U {https://gjzlx.sdfmu.edu.cn/CN/abstract/article_9493.shtml} %8 2014-10-29 %X mTOR signaling pathway is closely related to cell proliferation, cell cycle and other pathological processes about tumor. Rapamycin plays an antitumor effect through inhibiting mTOR, but it prone to drug resistance, which leads to limited clinical application. Its resistant mechanism is related with the activation of PI3KAkt, which is regulated with negative feedback. Dual inhibitors of related proteins of mTOR pathway are expected to reverse the drug resistance.