%A SONG Shu-An, PU Da-Xun, JIANG Tao, JING Qiong-You, WANG Jian-Bing %T Impact of the signal path PD-1/PD-L1 on Treg cells and tumor cells %0 Journal Article %D 2014 %J Journal of International Oncology %R 10.3760/cma.j.issn.1673-422X.2014.11.003 %P 808-810 %V 41 %N 11 %U {https://gjzlx.sdfmu.edu.cn/CN/abstract/article_9541.shtml} %8 2014-12-03 %X Programmed death1 (PD1) and its ligand PDL1 are the major members of inhibitory costimulatory molecules and express high in a variety of tumor cells and their associated cells surface, while the proportion of regulatory T cells (Tregs) are abnormally elevated in tumor infiltrating T lymphocytes cells. PDL1 combined with PD1 and Treg help tumors evade immune clearance, weaken immune responses and induce immune tolerance. New researches find that PDL1 plays an important role in the development and function maintenance of inducible Treg (iTreg), and PDL1 signal can change initial CD4+ CD25- T cells into iTreg to play a role of immunosuppression. Research on PD1 signaling pathway can provide a new theoretical basis for the inhibition of tumor immune escape in clinical application of immunotherapy and better treatments.