%A hang Xiaoying, Wang Xiaofang %T Microenvironment and the occurrence and development of cancer stem cells %0 Journal Article %D 2015 %J Journal of International Oncology %R 10.3760/cma.j.issn.1673-422X.2015.02.012 %P 126-129 %V 42 %N 2 %U {https://gjzlx.sdfmu.edu.cn/CN/abstract/article_9575.shtml} %8 2015-02-08 %X The occurrence and development of tumor depends not only on the tumor itself, but also depends on the soil survival of tumor cells, that is the tumor microenvironment. Studies confirm that the changes of blood vessels and hypoxic of tumor microenvironment maintain the stemness of cancer stem cell, and further strengthen the ability of tumor invasion and metastasis. Studying the molecular mechanism of tumor development from angiogenesis and lack of oxygen can provide new ideas for the clinical targeted therapy.