%A MA Yu-Lei, LI Hai-Yuan, ZHOU Chuan, ZHOU Feng-Hai, 吕Hai-Di , WANG Shi-Guang %T Roles of transforming growth factor-β1 in cancer stem cells %0 Journal Article %D 2014 %J Journal of International Oncology %R 10.3760/cma.j.issn.1673-422X.2014.12.005 %P 893-895 %V 41 %N 12 %U {https://gjzlx.sdfmu.edu.cn/CN/abstract/article_9589.shtml} %8 2014-12-24 %X Tumor stem cells are responsible for metastasis and relapse of cancer. Transforming growth factorβ1 (TGFβ1) plays an important role in the proliferation and differentiation of tumor stem cells. In many cancers such as breast carcinoma, hepatocellular carcinoma, pancreatic carcinoma, lung carcinoma, glioma and gallbladder carcinoma, the epithelialmesenchymal transition (EMT) induced by TGFβ1 can inhibit proliferation of cancer cell, enrich tumor stem cells and increase invasive capability and drug resistance of cancer.