%A WANG Tong, QI Xiao-Fei, ZHANG Ri %T Self-renewal mechanism of cancer stem cells %0 Journal Article %D 2014 %J Journal of International Oncology %R 10.3760/cma.j.issn.1673-422X.2014.12.006 %P 896-898 %V 41 %N 12 %U {https://gjzlx.sdfmu.edu.cn/CN/abstract/article_9591.shtml} %8 2014-12-24 %X Cancer stem cells comprise a subpopulation with the capacity of selfrenewal, selfdifferentiation and high tumorigenicity. Cancerogenesis, development, relapse and therapeutic resistance are closely related with these cells. The most important characteristics of these cells are the ability to selfrenew. So insight into the regulating mechanism of selfrenewal in cancer stem cells will be important for the development of novel molecular agents targeted the cancer stem cells.