%A GUO Yan-Xun-；Ma-Shi-Yin %T Antitumor effects of metformin %0 Journal Article %D 2015 %J Journal of International Oncology %R 10.3760/cma.j.issn.1673-422X.2015.04.011 %P 281-283 %V 42 %N 4 %U {https://gjzlx.sdfmu.edu.cn/CN/abstract/article_9645.shtml} %8 2015-04-08 %X Metformin as a cheap, safe and effective diabetes drug， has been used for many years. Recently, many studies have shown its variety inhibition of tumor cells. Its antitumor mechanism is not entirely clear; may be related to glucose metabolism and protein kinase or inflammatory cytokines mediating tumor killing. Metformin has different cytotoxic effects to various tumor cell, as well as playing some auxiliary roles on other antitumor methods.