%A LAI Xiang-Li-；Feng-Guo-Sheng %T Proto-oncogene Bmi-1 and non-small cell lung cancer %0 Journal Article %D 2015 %J Journal of International Oncology %R 10.3760/cma.j.issn.1673-422X.2015.04.015 %P 295-297 %V 42 %N 4 %U {https://gjzlx.sdfmu.edu.cn/CN/abstract/article_9649.shtml} %8 2015-04-08 %X B-cell specific moloney leukemia virus insertion site 1 (Bmi-1)gene is a core member of the polycomb group genes, considered to be a proto-oncogene; Bmi-1 plays an important role in cell selfrenewal, proliferation and apoptosis. Several studies have shown that Bmi-1 is highly expressed in non-small cell lung cancer; furthermore, the expression level of Bmi-1 is closely related to the occurrence, development, incursion and prognosis of nonsmall cell lung cancer. Bmi-1 is expected to become a novel tumor molecular marker, and provides a new direction for the treatment of non-small cell lung cancer.