%A Wang Yun, Li Yuhong %T Mechanism of Raf kinase inhibitor protein down-regulation in cancer %0 Journal Article %D 2015 %J Journal of International Oncology %R 10.3760/cma.j.issn.1673-422X.2015.10.008 %P 750-752 %V 42 %N 10 %U {https://gjzlx.sdfmu.edu.cn/CN/abstract/article_9790.shtml} %8 2015-10-08 %X Raf -kinase inhibiting protein (RKIP) plays a vital role in various physiological processes and participates in multiple signaling pathways, with a close releationgship with tumor. The mechanism of RKIP down-regulation in neoplasms includes transcriptional regulation, methylation, acetylation, histone modification, microRNA regulation and NF-κB/Snail/RKIP loop regulation.